Phenotypic variation in influenza virus reassortants with identical gene constellations
Identifieur interne : 002584 ( Main/Exploration ); précédent : 002583; suivant : 002585Phenotypic variation in influenza virus reassortants with identical gene constellations
Auteurs : Clayton W. Naeve [États-Unis] ; Robert G. Webster [États-Unis] ; Virginia S. Hinshaw [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1983.
Descripteurs français
- KwdFr :
- Animaux, Canards (microbiologie), Gènes viraux, Hybridation d'acides nucléiques, Hémagglutinines virales (génétique), Hémagglutinines virales (immunologie), Intestins (microbiologie), Recombinaison génétique, Réplication virale, Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (physiologie).
- MESH :
- génétique : Hémagglutinines virales, Virus de la grippe A.
- immunologie : Hémagglutinines virales, Virus de la grippe A.
- microbiologie : Canards, Intestins.
- physiologie : Virus de la grippe A.
- Animaux, Gènes viraux, Hybridation d'acides nucléiques, Recombinaison génétique, Réplication virale.
English descriptors
- KwdEn :
- Animals, Ducks (microbiology), Genes, Viral, Hemagglutinins, Viral (genetics), Hemagglutinins, Viral (immunology), Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (physiology), Intestines (microbiology), Nucleic Acid Hybridization, Recombination, Genetic, Virus Replication.
- MESH :
- chemical , genetics : Hemagglutinins, Viral.
- chemical , immunology : Hemagglutinins, Viral.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- microbiology : Ducks, Intestines.
- physiology : Influenza A virus.
- Teeft :
- Academic press, Animals, Antigenic, Assay, Avian, Avian influenza viruses, Cdna, Clonal phenotypic variation, Constellation, Digestive tract, Gene, Gene segments, Genes, Viral, Genotype, Hemagglutinin, Hemagglutinin gene, High titers, Hinshaw, Hong kong, Host range, Human strain, Hybrid, Hybridization, Hybridization analysis, Influenza, Influenza virus, Influenza viruses, Intestinal, Intestinal tract, Laver, Monoclonal, Monoclonal antibodies, Mutation, Neuraminidase, Nucleic Acid Hybridization, Other reassortants, Parental, Parental udorn strain, Parental virus, Parental viruses, Phenotypic, Phenotypic variation, Point mutations, Polyclonal, Reassortant, Reassortant viruses, Reassortants, Recombination, Genetic, Same gene constellation, Same genotype, Subunit, Tissue tropism, Tropism, Udorn, Udorn parent, Vertical agarose, Virus, Virus Replication, Vrna.
Abstract
Abstract: To determine which gene segments of influenza A viruses are responsible for the property of tissue tropism, reassortants were produced between the avian influenza strain, A/Mal/NY/6750/78 [H2N2] (Mal/NY), and a human strain, A/Udorn/307/72 [H3N2] (Udorn). The avian strain replicates in the intestinal tract of ducks and the human strain does not. Eight reassortants were shown by hybridization analysis to have the same gene constellation, having received hemagglutinin gene segment 4 from Udorn and the remaining seven gene segments from Mal/NY. With one exception, all reassortants containing the Udorn HA were restricted in their ability to traverse the digestive tract of ducks and replicate therein. The exception, reassortant R2, replicated to high titers in the intestinal tract. The R2 virus was shown to possess a hemagglutinin molecule that was antigenically distinguishable from the Udorn parent with polyclonal and monoclonal antibodies. The virus was “nonavid” in reaction with antihemagglutinin antibodies and was phenotypically similar to avian influenza viruses. The results suggest that the R2 hemagglutinin has undergone mutation(s) altering tissue tropism and antigenic properties of the virus. These studies illustrate the importance of the hemagglutinin gene in determining tissue tropism and present an example of phenotypic variation in a virus population with the same gene constellation but do not exclude a requirement for other gene products.
Url:
DOI: 10.1016/0042-6822(83)90260-X
Affiliations:
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Le document en format XML
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Hinshaw</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 48101</wicri:regionArea><wicri:noRegion>Tennessee 48101</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1983">1983</date><biblScope unit="volume">128</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="331">331</biblScope><biblScope unit="page" to="340">340</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Ducks (microbiology)</term><term>Genes, Viral</term><term>Hemagglutinins, Viral (genetics)</term><term>Hemagglutinins, Viral (immunology)</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (physiology)</term><term>Intestines (microbiology)</term><term>Nucleic Acid Hybridization</term><term>Recombination, Genetic</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Canards (microbiologie)</term><term>Gènes viraux</term><term>Hybridation d'acides nucléiques</term><term>Hémagglutinines virales (génétique)</term><term>Hémagglutinines virales (immunologie)</term><term>Intestins (microbiologie)</term><term>Recombinaison génétique</term><term>Réplication virale</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hémagglutinines virales</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Hémagglutinines virales</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Canards</term><term>Intestins</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Ducks</term><term>Intestines</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe 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ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: To determine which gene segments of influenza A viruses are responsible for the property of tissue tropism, reassortants were produced between the avian influenza strain, A/Mal/NY/6750/78 [H2N2] (Mal/NY), and a human strain, A/Udorn/307/72 [H3N2] (Udorn). The avian strain replicates in the intestinal tract of ducks and the human strain does not. Eight reassortants were shown by hybridization analysis to have the same gene constellation, having received hemagglutinin gene segment 4 from Udorn and the remaining seven gene segments from Mal/NY. With one exception, all reassortants containing the Udorn HA were restricted in their ability to traverse the digestive tract of ducks and replicate therein. The exception, reassortant R2, replicated to high titers in the intestinal tract. The R2 virus was shown to possess a hemagglutinin molecule that was antigenically distinguishable from the Udorn parent with polyclonal and monoclonal antibodies. The virus was “nonavid” in reaction with antihemagglutinin antibodies and was phenotypically similar to avian influenza viruses. The results suggest that the R2 hemagglutinin has undergone mutation(s) altering tissue tropism and antigenic properties of the virus. These studies illustrate the importance of the hemagglutinin gene in determining tissue tropism and present an example of phenotypic variation in a virus population with the same gene constellation but do not exclude a requirement for other gene products.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Naeve, Clayton W" sort="Naeve, Clayton W" uniqKey="Naeve C" first="Clayton W." last="Naeve">Clayton W. Naeve</name></noRegion><name sortKey="Hinshaw, Virginia S" sort="Hinshaw, Virginia S" uniqKey="Hinshaw V" first="Virginia S." last="Hinshaw">Virginia S. Hinshaw</name><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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